Can We Produce Heparin/Heparan Sulfate Biomimetics Using “Mother-Nature” as the Gold Standard?

Can we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?

Heparan sulfate (HS) and heparin are glycosaminoglycans (GAGs) that are heterogeneous in nature, not only due to differing disaccharide combinations, but also their sulfate modifications. HS is well known for its interactions with various growth factors and cytokines; and heparin for its clinical use as an anticoagulant. Due to their potential use in tissue regeneration; and the recent adverse ...

Biomimetics--using nature to inspire human innovation.

Evolution has resolved many of nature's challenges leading to lasting solutions. Nature has always inspired human achievements and has led to effective materials, structures, tools, mechanisms, processes, algorithms, methods, systems, and many other benefits (Bar-Cohen Y (ed) 2005 Biomimetics-Biologically Inspired Technologies (Boca Raton, FL: CRC Press) pp 1-552). This field, which is known as...

Standard Statistical Concepts: Can They Produce Incoherence?

The present article concerns statistical concepts that are usually presented in the statistical classroom. Examples are presented in a way that simple applications of these concepts produce incoherent conclusions. The examples illustrate that: iid random variables are in fact strongly dependent; conditional probabilities may depend on how the conditioning arguments were learned; confidence inte...

Interpretation of spirometry: we can do better than the GOLD standard.

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Can We Apply the Control Material from Standard Clinical Chemistry Analyzer for Usage in the Point of Care Testing Analyzer?